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Four
different consequences of the action of neurotransmitters. These events show
that the synapses and nucleus readily interact
- Transmitter activation of a ligand-gated ion channel
leads to a rapid synaptic action lasting milliseconds to seconds.
- Transmitter activation of a seven transmembrane
receptor and a second messenger kinase leads to a more enduring synaptic
action lasting minutes.
- Repeated transmitter activation of a seven
transmembrane receptor leads to the translocation of the kinase to the
nucleus and to activation of transcription, producing a persistent
synaptic action lasting days.
- Transmitter can also activate local protein synthesis
to stabilize the synapse-specific long-term facilitation.
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