Many experts would defer treatment in asymptomatic children aged >1 year with normal immune status in situations in which the risk for clinical disease progression is low (e.g., HIV RNA <100,000 copies/mL) and when other factors (i.e., concern for adherence, safety, and persistence of antiretroviral response) favor postponing treatment. In such cases, the health care provider should closely monitor virologic, immunologic, and clinical status.