These observations suggest that some common factor may be linking a number of high-risk phenotypes, in the absence of any changes in levels of systolic, diastolic, or even pulse pressure. One possibility is that this antecedent is related to activity of the renin-angiotensin-aldosterone system – many of these high risk phenotypes are influenced by ACE inhibitors, including the non-modulating phenotype. But once again the question as to whether insulin resistance is this common antecedent may be worth considering.

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