![](img010.GIF) |
It could be that improved glycaemic control significantly
reduced microvascular diseases, but not macrovascular. In this slide the risk of
myocardial infarction on the one hand and microvascular diseases on the other are related
to mean of glycated hemoglobin during entire study. What this implies is that the expected
benefit for glycemia improvement as for microvascular disease is concerned is much greater
that may be expected for large vessels disease and this indeed is what the intervention
part of the study shows. The UKPDS, even with 5000 patients, was underpowered to detect
the significant benefit of glycaemic control on large vessels diseases. |