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Pathogenesis:
Aerosol virus infects the ciliated epithelium of the nasal mucosa and then may extend to the bronchioles with resulting epithelial cell necrosis, which manifests as bronchiolitis and serous exudation. Clinical signs A harsh dry cough follows an incubation period of 1-3 days when the horse also develops pyrexia (103O-106OF), depression, loss of appetite, and enlarged submandibular lymph nodes. Secondary bacterial infection follows defective muco-ciliary transport. Streptococcus zooepidemicus can cause a purulent bilateral nasal discharge. A fatal bronchopneumonia is more likely if horses continue to be exercised. |