The mechanism of SJW's antidepressant effects is only partially known. Some in vitro studies demonstrated monoamine oxidase inhibition , but only at concentrations unattainable in vivo. Furthermore SJW is used extensively (66 million doses in 1994 in Germany) without reported side effects. Other reported application include: Tissue healer and anti inflammatory, the red oil of St John's Wort has appreciable benefit for the local treatment of wounds and burns. The herb although it has been seen as Anti –depressive, but the combination of actions has many applications to individual case. Menopausal depressions, headaches the type accompanying overwork or pressure perhaps at the end of the day or even, when the tension is suddenly let up at weekends. The plant has several useful applications to conditions of digestive system, the combination of relaxant, astringent, analgesic, antiseptic and healing properties makes it a good remedy taken orally for inflammatory events of the gut wall and the visceral spasm and pain that often accompanies them. Gastritis, enteritis (and accompanying diarrhoea), peptic ulceration are all indications.
SJW's has the reputation of opening obstructions and dissolving tumours. (refer to slide 24).