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The Insulin
Resistance Syndrome (or metabolic syndrome X) is a constellation of metabolic
disturbances, which enhance cardiovascular risk. The features of this syndrome are listed
in the slide and include the characteristic deposition of fat around the abdominal organs
called visceral or central adiposity. Characteristic changes in the lipoprotein profile,
seen in both the IRS and diabetes, are a decrease in the good cholesterol HDLc, a rise in
triglycerides and an increase in predominance of the dense LDL or phenotype B. An increase
in blood pressure is seen in many, but not all, insulin resistant populations while
increased fibrinogen, a clotting and inflammatory marker, and PAI-1, a fibrinolytic
marker, are also seen. |