When considering international research one is confronted in both developed and developing countries that are quit different than doing work within ones own country. Often American Investigators are interested in doing International research, for examine, but do not realize that the rules are different. Misperceptions can taint research, and in fact destroy research. The Global Pittsburgh concept is an open source model where we freely share information about research, research design, access, etc. It makes little sense the system we have now where all new international research starts anew, without using learning from the many mistakes that we all have made. International research needs to "stand on the shoulders of those who went before", as through connection and dialogue we can help others to not make the same mistakes as we. Global Pittsburgh is thus about communication.