Factors to be considered in deciding when to initiate therapy in such children include:
a. Increasing HIV RNA levels (e.g., HIV RNA levels approaching 100,000 copies/mL);
b. Rapidly declining CD4+ T cell count or percentage to values approaching those indicative of severe immune suppression (i.e., Immune Category 3; see Table 1);
c. Development of clinical symptoms; and
d. Ability of caregiver and child to adhere to the prescribed regimen.

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