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为了评估冠心病患病的影响因素, Rubins和他的同事们调查了美国老兵医疗中心的8,500名禁食脂质的冠心病患者.1在所有参加调查的冠心病患者中, 63% 的人 HDL-C 水平 < 40 mg/dL. 患有冠心病的非洲裔的美国人HDL-C水平平均值( 45 mg/dL )明显比白人高。这些数据表明国家胆固醇教育计划2 35 mg/dL 来作为划定低水平HDL-C 可能会严重低估冠心病的发病率
 
参考文献:
1. Rubins HB, Robins SJ, Collins D, et al. Distribution of lipids in 8,500 men with coronary artery disease. Am J Cardiol. 1995;75:1196?201.
2. National Cholesterol Education Program. Second Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). Circulation. 1994;89:1329?445.