RAAS interruption improvescardioprotection, improved insulin sensitivity, slow nephropathy - reduces membrane permeability to albumen, maxangial matrix expansion and intraglomerular pressure.  Influence adipocyte differentiation.

ACEI and ARB drugs not only effective in controlling hypertension and providing renal protection but also seem to be effective in lowering the odds of risk of developing Type 2 diabetes in those patients who are at risk.  Another reason for trying to identify those who are at risk.

Diabetes Care Sept. 2005.

Must watch renal function and potassium

Vasodilating Beta Blockers are useful in BP control, may improve insulin sensitivity.

ASA - 30% reduction in MI and  20% reduction in CVA