BIOGRAPHICAL SKETCH

NAME

Nathan D. Wong, Ph.D., F.A.C.C.

 POSITION TITLE

Associate Professor

EDUCATION/TRAINING

INSTITUTION AND LOCATION

DEGREE

(if applicable)

YEAR(s)

FIELD OF STUDY
Pomona College - Claremont, California

Yale University - New Haven, Connecticut

Yale University - New Haven, Connecticut

B.A.

M.P.H.

Ph.D.

1983

1985

1987

 Chemistry

Epidemiology

Epidemiology

RESEARCH AND PROFESSIONAL EXPERIENCE:

Positions and Honors:

1987 - Lecturer in Medicine, Department of Medicine, Yale School of Medicine - New Haven, Connecticut

1988-1994 - Assistant Adjunct Professor, Division of Cardiology, Department of Medicine, University of California, Irvine - Irvine, California

1997-1998 - Senior Investigator, Southern California Permanente Medical Group - Pasadena, California

1991-Present Director, Heart Disease Prevention Program, University of California, Irvine - Irvine, California

1994-Present Associate Adjunct Professor, Division of Cardiology, University of California, Irvine - Irvine, California

1995-Present Associate Adjunct Professor, Department of Epidemiology, University of California, Los Angeles - Los Angeles, California

1991-Present Fellow, American Heart Association, Council on Epidemiology and Prevention

1995-Present Fellow, American College of Cardiology

1998 -2001 Board of Directors, American Heart Association, Orange County Division, California

1996-2001 Member, California Cardiovascular Disease Prevention Coalition (Chair 1998-1999)

2001-Present Member, California Heart Disease and Stroke Advisory Committee

2001-Present Member, Board of Directors, Foundation for the Prevention of Cardiovascular Disease and Stroke

2002-Present Member, Cardiovascular Disease Prevention Committee, American College of Cardiology

Selected Publications (total of 54):

  1. Wong ND, Cupples LA, Ostfeld AM, Levy D, Kannel WB. Risk factors for long-term coronary prognosis following initial myocardial infarction: the Framingham Study. Am J Epidemiol 1989; 130: 469-80.
  2. Wong ND, Reading AR. Personality correlates of the Type A behavior pattern. Pers Indiv Diff 1989; 10: 991-6.
  3. Wong ND, Levy D, Kannel WB. Prognostic significance of the electrocardiogram
  4. following Q-wave myocardial infarction. Circulation 1990; 81: 780-9.
  5. Wong ND, Ming S, Zhou HY, Black HR. A comparison of Chinese and Western medical approaches for the treatment of mild hypertension. Yale J Biol Med 1991; 64: 79-87.
  6. Davidson DM, Van Camp J, Bates RD, Bradley BH, Grannis L, Iftener CA, Kelly KA, Landry SM, Wong ND. Family history fails to predict the majority of children with high capillary blood total cholesterol. J School Health 1991; 61(2): 75-80.
  7. Wong ND. La riduzione del cholesterolo: sfruttare al massimo i benefici. Aggiornamenti in Cardiologia (Italian), December 1991, 24-5.
  8. Wong ND, Wilson PWF, Kannel WB. Serum cholesterol as a risk factor post-myocardial infarction: The Framingham Study. Ann Intern Med 1991; 115: 687-93.
  9. Wong ND, Bassin S, Deitrick R. Relationship of blood lipids to body composition and family medical history in an ethnically diverse school-age population. Ethnicity and Disease 1991; 1(4): 351-63.
  10. Gardin JM, Wong N, Bommer W, Klopfenstein S, Smith VE, Tabatznik B, Siscovick D, Lobodzinski S, Anton-Culver H, Manolio TA. Echocardiographic design of a multi-center investigation of free-living elderly subjects: the Cardiovascular Health Study. J Am Soc Echo 1992; 5: 63-72.
  11. Wong ND, Hei TK, Qaqundah PY, Davidson DM, Bassin SL, Gold KV. Television viewing as a marker for pediatric hypercholesterolemia. Pediatrics 1992; 90(1): 75-9.
  12. Ettinger WH, Wahl P, Manolio T, Tracy R, Kuller L, Borhani N, Bush T, Wong N, O’Leary. Lipoprotein lipids in older people: results from the Cardiovascular Health Study. Circulation 1992; 86: 858-69.
  13. Goel M, Wong ND, Eisenberg H, Hagar J, Kelly K, Tobis JM. Risk factor correlates of coronary calcification as evaluated by ultrafast computed tomography. Am J Cardiol 1992; 70: 977-80.
  14. Brundage BH, Detrano RC, Wong ND. Ultrafast computed tomography: imaging of coronary calcium in atherosclerosis. Am J Cardiac Imaging 1992; 6(4): 340-5.
  15. Cupples LA, Gagnon DR, Wong N, Ostfeld A, Kannel WB. Pre-existing cardiovascular conditions and long-term prognosis following initial myocardial infarction: the Framingham Study. Am Heart J 1993; 125: 863-72.
  16. Bild DE, Fitzpatrick A, Fried LP, Wong N, Haan MN, Lyles M, Bovill E, Polak JF, Schulz R. Age-related trends in cardiovascular morbidity and physical functioning in the elderly: the Cardiovascular Health Study. J Am Geriat Soc 1993; 41: 1047-56.
  17. Morris GS, Vo A, Bassin SL, Wong ND. Distribution and correlates of tobacco use in a Hispanic youth population. J School Health 1993; 63(9): 391-6.
    18.
  18. Wong ND, Kowabunpat D, Vo A, Detrano R, Eisenberg H, Goel M, Tobis JM. Coronary calcium in asymptomatic men and women: relation to age and risk factors. Am Heart J; 127:422-30, 1994.
  19. Wong ND, Vo A, Abrahamson D, Tobis JM, Eisenberg H, Detrano RC. Coronary artery calcium evaluation by ultrafast computed tomography: relation to clinical evidence of coronary artery disease. Am J Cardiol; 73:223-7, 1994.
  20. Tell GS, Bild D, Borhani N, Kronmal R, Polak JF, Rutan G, Wong N. Correlates of seated blood pressure in community-dwelling older adults: the Cardiovascular Health Study. Hypertension; 23:59-67, 1994.
  21. Wong ND, Kashyap ML. Dyslipidemia in the elderly: Prevalence and implications for clinical management in the prevention of coronary artery disease (invited review). Cardiology in the Elderly; 2:348-54, 1994.
  22. Detrano RC, Wong ND, French WJ, Tang W, Georgiou D, Young E, Brezden OS, Doherty T, Brundage BH. Prevalence of fluoroscopic coronary calcific deposits in 1,461 high-risk asymptomatic subjects. Am Heart J; 127(6):1526-32, 1994.
  23. Detrano RC, Wong ND, Tang W, French WH, Georgiou D, Young E, Brezden OS, Narahara KA, Brundage BH. Prognostic significance of cardiac cinefluoroscopy for coronary calcific deposits in asymptomatic high risk subjects. J Am Coll Cardiol; 24(2):354-8, 1994.
  24. Wong ND, Gardin JM, Kurosaki T, Anton-Culver H, Roseman J, Giddin S. Echocardiographic left ventricular systolic function: distribution and factors affecting variability: The CARDIA Study. Am Heart J; 129:571-7, 1995.
  25. Tang W, Detrano RC, Brezden OS, Georgio D, French WJ, Wong ND, Doherty TM, Brndage BH. Racial differences in coronary calcium prevalence among high-risk adults. Am J Cardiol; 75(16):1088-91, 1995.
  26. Wong ND, Detrano R, Abrahamson D, Tobis JM, Gardin JM. Coronary artery screening by electron beam tomography: the facts, the controversy, and the future. Circulation; 92:632-36, 1995.
  27. Gardin JM, Wagenknecht LE, Anton-Culver H, Flack J, Gidding S, Kurosaki T, Wong ND, Manolio TA. Relationship of cardiovascular risk factors to echocardiographic left ventricular mass in healthy young black and white adult men and women: the CARDIA study. Circulation; 92(3):380-7, 1995.
  28. Wong ND, Teng W, Abrahamson D, Willner R, Henein N, Franklin SS, Kashyap ML, Rosenzweig B, Kukes G, Detrano RC. Noninvasive tracking of coronary atherosclerosis by electron beam computed tomography: rationale and design of the felodipine atherosclerosis prevention study. Am J Cardiol; 76:1239-42, 1995.
  29. Teng W, Wong ND, Abrahamson D, Gardin JM. Relation of electron beam computed tomography (EBCT) screening for coronary calcium to cardiovascular risk and disease: a review. Coronary Artery Disease; 7:383-9, 1996.
  30. Wang S, Detrano RC, Tang W, Doherty T, Puentes G, Wong N, Brundage BH. Detection of coronary calcium with electron beam computed tomography: evaluation of inter-examination reproducibility and comparison of three image acquisition protocols. Am Heart J; 132:550-558, 1996.
  31. Wong ND, Detrano RC, Diamond G, Rezayat C, Mahmoudi R, Chong C, Tang W, Puentes G, Kang X, Abrahamson D. Does coronary artery screening by electron beam computed tomography motivate healthy lifestyle behaviors? Am J Cardiol; 78:1220-3, 1996.
  32. Wong ND, Gardin JM. Noninvasive assessment of and newer therapies for influencing atherosclerosis progression and regression. Antiatherosclerotic Agents: Investigational Drugs Research Alert; 2(4):141-8, 1997.
  33. Gardin JM, Arnold A, Gottdiener JS, Wong ND, Fried LP, Klopfenstein HS, O’Leary DH, Tracy R, Kronmal R. Left ventricular mass in the elderly: the Cardiovascular Health Study. Hypertension; 29(5):1095-1103, 1997.
  34. Franklin SS, Gustin W, Wong ND, Larson MG, Weber MA, Kannel WB, Levy D. Hemodynamic patterns of age-related change in blood pressure: the Framingham Heart Study. Circulation; 96:308-15, 1997.
  35. Detrano RC, Wong ND, Doherty TM, Shavelle R. Prognostic significance of coronary calcific deposits in asymptomatic high-risk subjects. Am J Med; 102:344-9, 1997.
  36. Secci A, Wong N, Tang W, Wang S, Doherty T, Detrano R. Prognostic significance of cardiac cinefluoroscopy for coronary calcific deposits in asymptomatic high-risk subjects: three year follow-up. Circulation; 96: 1122-9, 1997.
  37. Kasaoka S, Tobis JM, Akiyama T, Reimers B, Di Mario C, Wong ND, Colombo A. Angiographic and intravascular ultrasound predictors of in-stent restenosis. JACC; 32(6):1630-5, 1998.
  38. Doherty TM, Wong ND, Shavelle RM, Teng W, Detrano RC. Coronary heart disease deaths and infarctions in people with little or no coronary calcium. Lancet; 353:41-2, 1999.
  39. Hosobuchi C, Rutanassee L, Bassin SL, Wong ND. Efficacy of acacia, pectin, and guar gum-based fiber nutrient supplementation in the control of hypercholesterolemia. Nutrition Research; 19:643-9, 1999.
  40. Detrano RC, Wong ND, Doherty TM, Shavelle RM, Tang W, Doherty TM, Ginzton LE, Budoff MJ, Narahara KA. Coronary calcium does not accurately predict near-term future coronary events in high-risk adults. Circulation; 99:2633-8, 1999.
  41. Franklin SS, Khan SA, Wong ND, Larson MG, Levy D. Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham Heart Study. Circulation; 100:354-360, 1999.
  42. Wong ND, Hsu JC, Detrano RC, Diamond G, Eisenberg H, Gardin JM. Coronary artery calcium evaluation by electron beam computed tomography and its relation to new cardiovascular events. Am J Cardiol; 86:495-8, 2000.
    43.
  43. Wassertheil-Smoller S, Anderson G, Psaty BM, Black HR, Manson J, Wong ND, et al. Hypertension and its Treatment in Post-Menopausal Women: Baseline Data from the Women’s Health Initiative. Hypertension; 36:780-9, 2000.
  44. Franklin SS, Jacobs MJ, Wong ND, L’Italien GJ, Lapuerta P. Predominance of isolated systolic hypertension among middle-aged and elderly US hypertensives. Hypertension; 37; 869-74, 2001.
  45. Franklin SS, Larson MG, Khan SA, Wong ND, Leip EP, Kannel WB, Levy D. Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study. Circulation; 103: 1245-9, 2001.
  46. Wong ND, Pio J, Valencia R, Thakal G. Distribution of C-reactive protein and its relation to risk factors and coronary heart disease risk estimation in the National Health and Nutrition Examination Survey (NHANES) III. Prev Cardiol 2001; 4: 109-115.
  47. Wong ND, Budoff MJ, Pio J, Detrano RC. Coronary calcium and cardiovascular event risk: Evaluation by age- and sex-specific quartiles. Am Heart J. 2002 Mar;143(3):456-9.

 Book: Wong ND (editor-in-chief), Black HR, Gardin JM, eds. Preventive Cardiology, McGraw-Hill, New York, 2000, 630pp.

 Research Support (Ongoing)

N01-WH-4-2107 (Hubbel) 10/1994-9/2007   NIH / NHLBI

Women’s Health Initiative (UC Irvine Clinical Center)

Observational study and clinical trial enrolling a total of approximately 160,000 postmenopausal women aged 50-79 nationwide (approximately 3,600 at UC Irvine) to examine risk factors for coronary artery disease, cancer, and other diseases, and the efficacy of estrogen replacement therapy, low-fat dietary counseling, and calcium/vitamin D therapy on reducing the risk of certain diseases.

N01-HC-95169 (Detrano) 11/1999-10/2008   NIH / NHLBI

Subcontract from Harbor-UCLA (Wong, PI)

Multiethnic Study of Atherosclerosis (MESA) CT Reading Center

Longitudinal investigation of 6,500 high-risk men and women among multiple field centers, examining relation of risk factors and subclinical disease measures, including EBCT coronary calcium, with the occurrence of clinical cardiovascular disease. The EBCT reading center will conduct standardized interpretation of EBCT scans done in study participants and report results to the coordinating center.

 

N01-HC-45134 (Wong) 4/2001-3/2003  NIH/ NHLBI

Coronary Artery Risk Development in Young Adults (CARDIA) Echocardiography Reading Center

Longitudinal investigation of approximately 5,000 young adults at multiple US field centers, examining the development and progression of cardiovascular risk factors and relation to subclinical cardiovascular disease. The Echocardiography Reading Center has conducted readings of echocardiograms done in Years 5 and 10, with the current contract exclusively involving analysis of echocardiography data as it relates to major CARDIA hypotheses and other risk factors and measures of subclinical disease.

Axis-Shield (Wong) 1/2000 – 3/2002

Role of Factor XIIa and Other Circulating Factors in Predicting Subclinical Atherosclerosis as Measured by Coronary Artery Calcium. Case-control study examining relation of lipids and other cardiovascular risk factors and biomarkers to coronary calcium

UC Irvine Samueli Center for Complementary Medicine (Wong)   4/2000-12/2002

Lipid-Lowering, Antithrombotic, and Antiinflammatory effects of Ayurvedic Therapies. Clinical trial examining efficacy of a cholesterol protective Indian traditional herbal compound on lipids and other cardiovascular risk factors and biomarkers in persons with moderately elevated cholesterol levels. Samueli Center for Complementary and Alternative Medicine, UCI College of Medicine

Phytopharm, Inc. (Wong) 4/2000 – 6/ 2002

Efficacy of Cardiopril on Lipids and Other Risk Factors and Biomarkers. Clinical trial examining effect of herbal supplement product on lipids and other risk factors.