The classic treatment is streptomycin 15-20 mg/kg/day for 10 days.

Due to the inconvenience of intramuscular administration, especially in children, the drug of choice is rifampicin 10 mg/kg/day for 10-14 days, which has shown to diminish the time of healing lesions.

Chamberlin J, Laughlin L, Gordon S, Romero S, Solórzano N, Regnery R. Serodiagnosis of Bartonella bacilliformis infection by indirect fluorescence antibody assay: test development and application to a population in an area of bartonellosis endemicity. J Clin Microbiol 2000; 33:4269-71.