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front |1 |2 |3 |4 |5 |6 |7 |8 |9 |10 |11 |12 |13 |14 |15 |16 |17 |18 |19 |20 |21 |22 |23 |24 |25 |26 |27 |28 |29 |30 |review |
 Number of patients |
Size
of randomized trials in myeloma Only 40 trials (~30%) had sufficient power (beta=0.2) to detect a 20% difference in survival at 5 years; only 1 trial (<1%) was sufficiently powered to detect 10% survival difference at 5 years. (Ann Oncology 2001; 12: 1611-1617) |