Risk Factors for Intrathoracic Tuberculosis in the Economic Migrant Population of Two Dominican Republic Bateyes
Keri A. Cohn, MD, DTMH1, 3 Rodney Finalle, MD,1, 4, 5 Geraldine O’Hare, CRNP,1, 4 Jesús M. Feris,5 Josefina Fernández,5 and Samir S. Shah, MD, MSCE1, 2, 3, 6, 7, 8
From the 1Alliance for International Medicine, the Divisions of 2Infectious Diseases and 3General Pediatrics, and the 4Department of Primary Care, The Children’s Hospital of Philadelphia, Philadelphia, PA, the 5Departamento de Enfermedades Infecciosas, Clinica Infantil, Robert Reid Cabral, Santo Domingo, Dominican Republic, and the Departments of 6Pediatrics and 7Epidemiology, and the 8Center for Clinical Epidemiology and Biostatistics, the University of Pennsylvania School of Medicine, Philadelphia, PA.
Running title: Tuberculosis in the Dominican Republic Bateyes
Address for correspondence: Dr. Samir S. Shah, Division of Infectious Diseases, The Children’s Hospital of Philadelphia, Room 1526, North Campus, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104. Telephone: 215-590-4378; Facsimile: 215-590-0426; E-mail: shahs@email.chop.edu
Abstract
Refugees and economic migrants are high-risk populations for tuberculosis, particularly if they originate in countries with a high incidence of disease. We conducted a cross-sectional study to identify risk factors for intrathoracic tuberculosis among children living in migrant populations in the Dominican Republic bateyes. Definite or possible tuberculosis was diagnosed in 83 (20.8%) of 400 children. Unpasteurized milk consumption was identified as an independent risk factor for intrathoracic tuberculosis (adjusted odds ratio, 3.2; 95% confidence interval: 1.4-7.4) even after adjusting for Bacille Calmette-Guérin vaccination, household size, tuberculosis contacts and age and under varying assumptions about children diagnosed with “possible” tuberculosis. Our data raise the possibility that the high prevalence of tuberculosis in the Dominican Republic bateyes may be attributable to Mycobacterium bovis rather than Mycobacterium tuberculosis infection.