Speaker Details

Biography

Research interest Bioprocess scale-up and scale-down, high cell density cultivation, recombinant protein expression in microbial host with focus on host physiology and difficult-to-express proteins. Automation of process development and high throughput processing. Application of mathematical models in bioprocesses. Process Analytical Technologies. Single use bioreactors for microbial processes. Scientific education: 1992 PhD in Microbiology, Universität Greifswald 1988 Diploma in Biology/ Technical Microbiology, Universität Greifswald Employment since 2008 Professor for Bioprocess Engineering at the Technische Universität Berlin, Germany 2000 – 2008 Full Professor for Bioprocess Engineering, University of Oulu, Finland 1995 – 2000 Senior researcher / head of fermentation group, Universität Halle-Wittenberg 1993 – 1995 Postdoc, Royal Institute of Technology 1988 – 1993 Research assistant, Universität Greifswald Publications: 170 peer reviewed articles, 27 Reviews and book articles, 16 patents Supervision: so far 36 finalised PhD studnents

Abstract

Industry 4.0 in Biotechnology: How automation, robotics and digitalization can help to unlock the nature´s potential for new sustainable bioprocesses and bioproducts

The efficient use of automatically running robotic stations for the development of microbial processes can be only achieved by the integration of advanced methods for the model based Optimal Experimental Design (OED) to consider the nonlinear dynamics of the process. We developed a “lab of the Future” concept by combining robots with automatically running modelling and data collection tools, which continuously re-design the experiment based on the analytical data which are generated during an experiment with the aim to generate a valid process model within a single experiment. All these methods are integrated in a framework to create an intelligent laboratory for rapid characterization of biosystems. The strength of these methods will be demonstrated at the example for biocatalytic and biopharmaceutic bioprocesses.