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front |1 |2 |3 |4 |5 |6 |7 |8 |9 |10 |11 |12 |13 |14 |15 |16 |17 |18 |19 |20 |21 |22 |review |
Y-axis: Incidence (/year/100,000), X-axis: age |
The peak onset of MS occurs in the late 30s. It has been suggested that
pubertal and sex hormone factors play a role. If the hit occurs at
puberty, what does the age at onset curve tell us?
It may be that the "hit" does occur at puberty (-12 years), but the latency of disease is 20 years before symptoms appear. |