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In collaboration with Joe
Blondeau we also measured MPC for about 150 clinical isolates of S. pneumoniae to compare
fluoroquinolones. Since activity measurements are meaningless without consideration of
pharmacokinetics, we show MPC relative to drug concentrations achieved with standard
doses. What you see is that moxifloxacin is above its MPC for roughly half a day while
levofloxacin, at the standard 500 mg dose, never reaches MPC. Thus we would predict that
moxifloxacin would be more effective than levofloxacin at restricting the development of
resistance. |