Also see Amyloid and Amyloidosis 1993, edited by R Kisilevsky, M D Benson. On the amyloid cascade see http://neurobiologyoflipids.org/amyloidcascade.html. On the neurobiology of lipids, especially cholesterol, see http://clinmed.netprints.org/cgi/content/full/2001100005v1. Effective intervention for Alzheimer's disease may involve interfering with the multiple steps within the AD pathogenetic β-amyloid cascade. Therapies might involve interruption of neuronal cell death, inhibition of the inflammatory response in the neuritic plaques and the use of insulin-like growth factors and hormonal therapies like estrogen therapy.