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Performance des tests : hospital series (institution-based ) vs.
population-based results – e.g., population-based studies have
reported sensitivities in the range 24-38% whereas Eurofetus
(institution-based) study reported a sensitivity of 61%.
Differences are due in part to : selection (prevalence in the study
population and severity of the anomalies – more severe are more
often detected) + operator-dependent issues – training, etc – in
particular true for ultrasound screening. Other reasons: exclusions
(malformations not detectable by u/s) – false positives assessed or
not – routine u/s or not, etc
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