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To analyze the controls that regulate viability,
multiplication, and differentiation of normal hematopoietic cells, it is
desirable and convenient to study the entire process in cell cultures
starting from single cells. Therefore, my analysis began with the
establishment of a cell culture system for the cloning and clonal
development of different types of hematopoietic cells. This cell culture
system made it possible to discover a family of cytokines that regulate cell
viability, multiplication, and differentiation of different hematopoietic
cell lineages; to analyze the changes in normal controls in some
hematological diseases including leukemia; and to identify new ways of
treating these diseases.
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