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ICHV is now largely controlled by vaccination in the UK using tissue culture adapted virus which is used either alive or inactivated. Some dog breed societies (e.g. Afghans, Red Setters and Saluki) consider the live vaccines to be contra-indicated because of keratitis 1-3 weeks after vaccination. Keratitis results from CAV 1 replicating in the ciliary body and entering the anterior chamber. Antibody passes into the aqueous humour and immune complexes of CAV-1 and antibody activate complement. PMNs then bind the complexes via C1q and release proteases, collagenases, elastases and oxygen radicles. These radicles cause the corneal oedema and opacity - blue eye (local Coombs type 111). The keratitis is likely to heal in a few days once virus replication has finished. The cornea can be protected against secondary infection by antibiotic eye drops. Cortisone, which delays repair and increases the chance of corneal rupture, should not be used.