Ways of bypassing maternal immunity include giving repeat vaccinations to allow for differing levels of maternal antibody in different individuals and giving the vaccine in an adjuvant so it is released over several weeks.

With regard to pet animals the second vaccine used to be given at 12 weeks and the puppy was isolated indoors until 14 weeks. Final vaccination at 10 weeks and going outside at 11 weeks is now frequent so the puppy can become well-socialised to other dogs, people and traffic before they reach 4m when the behavioural-window for socialisation is closing.

With regard to farm animals vaccination may be delayed until they are 6m old.

Some vaccines against diseases which occur primarily in the new-born are given only to the mother only to provide a high maternal immunity eg to rotavirus of calves.