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Pathogenesis: The bovine virus and the human virus do not cross infect. Primary replication in the nasal epithelium then replication throughout the epithelium of the upper respiratory tract and bronchial tree. Syncytia formation occurs and these can be seen shed into the bronchioles. Some cases are complicated by oedema and emphysema. Epidemiology Subclinical reinfections may be important in spreading infection; more than 70% of cattle in the UK have neutralising antibody to RSV. |