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Replication:
Retrovirus replication is most unusual. Single stranded nucleic +veRNA is transcribed to -veDNA by the reverse transcriptase protein which is released during uncoating. -veDNA becomes circular double stranded ąDNA which is integrated into host cell chromosomes by a second viral enzyme, a DNA integrase. Chromosomal proviral DNA then codes for viral proteins and viral RNA using cellular enzymes and organelles. The rate of virus production from the cell is slow and cells continue to divide. |