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•National Biomedical Research Foundation (NBRF) => Protein Identification Resource (PIR)
–Margaret Dayhoff
–Atlas of Protein Sequences
–Phylogenies, evolution, amino acid substitution matrices (PAM) and discovering active sites in enzymes
–PIR SF Evolutionary Family , iProClass Functional site analysis and ontologies , iProLink to literature
–UniProt - Universal Protein Resource
–Amos Bairoch
–Manual curation and annotation
–Highly cross-referenced
–Many useful analytical tools (EXPASY Tools)
–2D-PAGE and Mass Spectrometry databases
–Prosite functional motif database
–UniProt - Universal Protein Resource
•TREMBL
–Translation of mRNAs (RefSeq), UniGene, open reading frames (ORFs) and predicted genes from genomes
–Automatic annotations
–Clusters
–Interpro linked to domain and motif databases (CATH , PANTHER , PRINTs, PROSITE, pFAM, PIRSF, PRODOM, SCOP, SMART, SUPERFAMILY)
–Intron-exon structure and links to ORFs, coding regions
–UniProt - Universal Protein Resource
–Protein and nrPRO database SwissProt, PIR and translated genes/genomes
–Protein Clusters Database (prokaryotic) and COGS and KOGS
–Linked to coding regions and intron/exon structure
–Linked to coding SNPs and variations databases
–Linked to MMDSB structure database
–Linked to 3D domains
–Linked to CDD Conserved Domain Database