LDL-C reductions with a starting dose of different statins vary from 19% with fluvastatin to 27% with pravastatin, 28% with lovastatin, 35% with simvastatin, and 37% with atorvastatin.

Doubling of a statin dose generally achieves a modest, 5%-6% incremental LDL-C reduction (“the rule of 6”).

Three doublings of the atorvastatin dose (from 10 mg to 80 mg) result in LDL-C reduction 18% greater than that achieved with the starting dose (10 mg).