These are data from a patient who was participating in one of our research studies on a once a day dosing regimen. Subjects were monitored for 12 months. At initial monitoring we had very good adherence. We suspect, because this is a very rare finding, that this is probably a reflection of the newness of being monitored and the awareness that somebody was going to be looking at how they were doing with their medication. Very soon, about a week and a half, you're beginning to see a picture which is much more commonly found now where medication may be missed for an entire day and then taken twice the next day to make up for it. Unfortunately, as you can see here, the timing is quite close. This is an individual with rheumatoid arthritis. There is a possibility that after the first twelve days, people start to feel better and so start forgetting to take their medication, and if this pattern were occurring two or three weeks into the experience I'd think that that's in fact what was going on. But given that we have such a good pattern at the onset of monitoring I suspect that it's more a function of the observation. From the very limited reports, we should find that with the pattern of adherence to exercise regimen parallels once a day dosing regimens to some extent, so that there are people who will cluster their exercise, not necessarily within the day, but perhaps on the weekend. They get in their three episodes of exercise during a week but it may occur on Friday, Saturday and Sunday. Then there's a long period of time where the regimen doesn't get enacted at all. In terms of the problem with self-reporting, theorists say that we summarize from most recent events, and if our most recent event was positive - that we were complying - then we telescope backwards in time with our memory, reporting that we have been doing fine all along.