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If you look at
the long range preeclampsia outcome, the study that was done by Leon Shesley shows that if
you took women who have eclampsia, (which is seizures, and preeclampsia was originally
recognized as predisposing you to seizures - it turns out that most women who have
preeclampsia don’t get seizures) you really have preclampsia. If they had eclampsia in a
later pregnancy, which we think is probably a surrogate for recurrent preeclampsia based
on some work we’ve done, they had a greatly increased risk of cardiovascular disease in
later life. The conclusion that was reached was: preeclampsia doesn’t cause
cardiovascular disease in later life, and if you have it in any pregnancy other than the
first, there’s probably something else going on. So this was Leon Shesley’s work. |