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Much of the epidemiologic literature is supportive of a
beneficial effect of Phytoestrogens in cancer prevention. However, the
literature is limited, And it may be that phytoestrogens are merely a marker
of a healthy Diet and lifestyle. The biologic mechanisms by which
phytoestrogens affect cancer need to be better elucidated. Much of the
previous work suggesting a protective effect has involved populations
consuming whole foods high in these compounds. It is unclear how
phytoestrogens in isolation, or at levels higher than those obtainable
through diet will behave in vivo. As you might recall, in vitro studies have
shown concentration specific effects. We
also need improved methods of quantifying phytoestrogen exposure, either
Through biomarkers or assessment of dietary intake. The popularity of
Phytoestrogens currently has resulted in the addition to foods of either
Isolated isoflavones or soy products. Our current food composition data Do
not reflect these potential sources of exposure. Finally, genetic
susceptibility may be important. Certain individuals may benefit Or
conversely be more likely to suffer harm because of genetically determined
Metabolic differences. Addressing these issues will help to clarify the
impact Of these compounds on cancer risk.
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