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Endothelium-independent relaxation evoked by sodium nitroprusside (10-16 to 10-4 M) in aortic rings gathered from normoglycemic, 4-week alloxan-diabetic rats treated with saline or D-chiro-inositol (20 mg/kg/12h). The data are expressed as mean ± SEM of six experiments. * p<0.05, (diabetic + D-chiro-inositol vs. diabetic + saline), ANOVA followed by Bonferroni.