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A robust epidemiological feature of
schizophrenia is the slight excess of births in winter and spring in the
temperate regions of the Northern Hemisphere. This points towards a risk
factor (such as lower winter sunlight or increased winter infection)
operating pre- or peri-natally rather than around the time of onset, Also, while the seasonal excess is small it may have a larger impact. For example, a comprehensive Danish record-linkage study found that the small seasonal excess of schizophrenia births (relative risk = 1.11) was associated with a sizeable (10.5%) population attributable fraction (PAF) for the disorder. The reason for this high PAF is that birth in winter or spring is a common exposure. In other words, because so many people are born winter or spring, a relatively small increase in risk would cause a large increase in the numbers of people with the schizophrenia. |