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People with a history of colorectal cancer in one or more first degree relatives are at increased risk (approximately double with a single affected first degree relative)
American Cancer Society
 
In general, hyperinsulinemia, such as in type 2 diabtes, is associated with colon cancer pathogenesis.
Frezza, et al. “Influence of obesity on the risk of developing colon cancer.” Gut.  2007: 56(7)1034-5.