Note: It should be noted here that the bioassay requires the use of mice. Not rats, guinea pigs or elephants. However, toxicologists insist on using rats. I don’t know why. Rats will not work well, their sensitivity is too low and systemic toxic effects interfere with measurement of the response, particularly for solvents. I don’t know how many times I have said this. My secretary is aware of this, from years of typing my material. Toxicologists seem to have the idea that only rats can be used!