 |
The major effects of temeperature and
functional activity, contractile and electric work, on the metabolic rate of myocardium
have been described. Institution of CPB permits emptying of the heart significantly
reducing contractile work and myocardial oxygen consumption, MVO2. Aortic cross clamp application induces ischemia while
achevingcardiac arrest. It results in greater reduction in myocardial oxygen consumption
than other preservation strategies.The content of cardioplegia must be designed not only
to arest the heartn but also to optimally maintain the integrity of myocardial cells
during the ischemic period. |
