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Ribavirin therapy is associated with certain side effects, including
  • Hemolytic anemia
  • Teratogenicity
  • Cough and dyspnea
  • Rash and pruritus
  • Insomnia
  • Anorexia
    •

    Combination IFN/RBV therapy, however, has been found to be relatively safe and consistent with the safety profile of each agent when used alone. Use of the 2 agents in combination is not believed to result in an increase of adverse effects.

    References

    Maddrey WC. Safety of combination interferon alfa-2b/ribavirin therapy in chronic hepatitis C-relapsed and treatment naïve patients. Semin Liver Dis. 1999;19(suppl 1):74.

    Rebetronä [package insert]. Kenilworth, NJ: Schering Corp; 1999.