Healthcare providers should have comprehensive knowledge of the toxicity profile of each agent before selecting a new regimen.
In the event of drug intolerance, change of a single drug in a multidrug regimen. In certain circumstances, a dose reduction is a permissible option. However, antiretroviral drugs should only be reduced to the lower end of the therapeutic range for those antiretrovirals for which an effective dosing range is known, and adequacy of antiretroviral activity should be confirmed by the monitoring of HIV RNA levels.