A comprehensive assessment of adherence issues should be instituted for all children in whom antiretroviral treatment is being considered.
Evaluations should include nursing, social and behavioral assessments.
Intensive follow-up is required particularly during the critical first few months after therapy is started.
Coordinated, comprehensive, family-centered systems of care often can address many of the daily problems facing families that may affect adherence to complex medical regimens.
Children may be developmentally younger than their chronologic age or their unwillingness to take medication may reflect an appropriate developmental task.