We developed a risk
algorithm, which considered a child’s age, their family history of
T1D, their HLA-DQ genotype and the similarity of their genotype to
the T1D child’s genotype using data from a family study we conducted
several years ago. This study
was based on families with a least 1 T1D child.
However, the T1D individuals were ~42 years of age when the
families were studied.
Therefore, any sibling who was going to develop T1D had likely
already had done so – since the peak age of T1D onset is at puberty.
Therefore, our T1D risk estimates were as accurate as
possible.
