The neurogenic differentiation factor 1 gene (NEUROD1; OMIM 601724) on chromosome 2q32 is MODY6. This gene is involved in the differentiation of neurons. It regulates insulin gene expression by binding to a critical motif on the insulin promotor.

MODY6 mutations are a rare cause of MODY. Only a few genetic variants, including missense and nonsense mutations have been identified.