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- CRASH Coordinating centre will provide you
with all treatment packs - The treatment is a loading infusion of 100mL, given over one hour - Followed by an infusion of 20mL per hour for 48 hours, or until discharge, if this is sooner - Each treatment pack contains - 11 x 2gm vials of methylprednisolone (MP) or placebo - an intravenous infusion set - CRASH stickers to be attached to the bags and to the front cover of the patient notes (The steroid dosing regimen is that used in the NASCIS 2 and NASCIS 3 trials of MP in acute spinal cord injury. However, fixed doses will be used in order to simplify the procedure. A 48-hour corticosteroid infusion is being tested because recent trials of MP in acute spinal cord injury have indicated slightly more neurological recovery with 48 than with 24 hours.) |