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An experiment has been performed
that fits with the ideas in the previous slide. In a small clinical trial (about 60
HIV-positive tuberculosis patients) treatment was with the standard therapy for 2 months
to suppress disease. The patients were then separated into two groups to test the idea
that rifapentine, a long-lived derivative of rifampicin, could be used less frequently
than rifampicin. In each group the number of relapses was similar at about 10%. But the
number of rifampicin-resistant cases was quite different: 0% with rifampicin, 80% with
rifapentine (16). |