Let’s start then by considering whether intervention with risk factors may be the answer to reducing diabetic cardiovascular mortality. UKPDS attempted to answer the question is whether euglycaemic control could improve cardiovascular risk.

Patients were randomized after 3 month running on diet alone either intensive therapy with insulin or sulfhonylureas or conventional therapy, predominantly diet based. During entire period intensive treatment gave 1% in lowering of HbA1c compare to conventional group.