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As you will recall, the UK prospective diabetes study failed to show the significant benefit in terms with macrovascular disease. This slide shows the incidence of acute myocardial infarction in 2 groups. The intensive glycaemic control was associated with 11% increase in the risk of stroke compare to subjects on conventional treatment. This means that in many macrovascular disease studies, coronary heart disease and other macrovascular events are combined the benifits of type of glycaemia are completely insignificant.