The action of ACTOS results in enhancement of insulin action and subsequent reductions in insulin secretion. ACTOS helps normalize glucose levels by increasing peripheral glucose utilization and decreasing hepatic glucose production. These effects are mediated by regulating the transcription of genes that encode polypeptides involved in carbohydrate, lipid, and protein metabolism.

ACTOS Package Insert, February 2000.
Sonnenberg GE, Kotchen TA. Curr Opin Nephrol Hypertens. 1998;7:551-555.