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Kappa = (Po - Pe)/(1 - Pe)
 
Where:
Po = A + D
 
Pe = [(A+B)*(A+C) + (C+D)*(B+D)]/N2
 
Po = Proportion of subjects observed to be concordant*
Pe = Proportion of subjects expected to be concordant*, based on chance alone
N =Total number of subjects
 
*Where both sources of data agree that subject either has presence or absence of disease