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The formation of amyloid plaques may rely on the APOE є4 gene.
Therefore, drugs that affect the levels
of
ApoE protein in the brain may prevent the formation of fibrils, inhibit
deposits or promote the removal of amyloid.
This process may result in slowing or delaying the development
of AD symptoms.
Researchers at the University of Washington at Seattle showed
that having the APOE є4 allele impacted
age
at on-set of the disease by as much as 17 years (Warwick Daw et al.
2000).
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