Hosts : Cloven-hoofed animals, i.e. cattle, sheep, goats, pigs, deer, elephants, and many otherwild ruminants such as buffalo, impala and kudu in Africa (Not horses).
Guinea pigs which develop vesicles are the experimental host for vaccine studies and antiserum production.
Suckling mice which die with myocarditis after experimental injection. The UK is still infected with the Pan Asian O strain several months after its introduction. Disease has persisted unseen in sheep on hill farms and is inadvertently spread by personnel and lorries with contamination of roads. The outbreak has cost the taxpayer and tourist industry billions of punds and this will accelerate a revaluation of the function of UK farming in the enlarged EU.