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In cattle,
vesicles (containing up to108TCID50/0.1ml) appear inside the mouth
and around the muzzle, in the interdigital cleft and around the coronary band and on the
teats. These lesions cause excessive salivation, smacking of the lips, and anorexia,
lameness and then secondary mastitis. Internally, lesions may be found in the oesophagus
and fore-stomachs. FMDV is a thus very painful disease with a rapid loss of
condition and milk yield but most adult animals survive.
In sheep and pigs disease is less obvious but vesicles are common around the
nose, mouth and coronary band. Exungulation is common in pigs, and was noted at the
RVC in ?1970 when gnotobiotic pigs in an isolator were infected with a contaminant FMDV.
The FMDV was in an ampoule of freeze dried attenuated pestivirus sent from France for the
contract-production of monospecific antiserum.
Death from myocarditis occurs in calves, lambs and piglets without
maternal antibody to FMDV. |
