The discovery of insulin in 1921 at the University of Toronto was lead by Frederick Banting, November 14, 1891 – February 21, 1941, Charles Best, 1899–1978, James B Collip, November 20, 1892 – June 19, 1965, and John J. R. Macleod, 6 September 1876 – 16 March 1935.